Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

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<jats:p> The recent positional cloning of the mouse <jats:italic>ob</jats:italic> gene and its human homolog has provided the basis to investigate the potential role of the <jats:italic>ob</jats:italic> gene product in body weight regulation. A biologically active form of recombinant mouse OB protein was overexpressed and purified to near homogeneity from a bacterial expression system. Peripheral and central administration of microgram doses of OB protein reduced food intake and body weight of <jats:italic>ob</jats:italic> / <jats:italic>ob</jats:italic> and diet-induced obese mice but not in <jats:italic>db</jats:italic> / <jats:italic>db</jats:italic> obese mice. The behavioral effects after brain administration suggest that OB protein can act directly on neuronal networks that control feeding and energy balance. </jats:p>

Journal

  • Science

    Science 269 (5223), 546-549, 1995-07-28

    American Association for the Advancement of Science (AAAS)

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