Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
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- Alexandra-Chloé Villani
- Broad Institute of MIT and Harvard, Cambridge, MA, USA.
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- Rahul Satija
- Broad Institute of MIT and Harvard, Cambridge, MA, USA.
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- Gary Reynolds
- Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
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- Siranush Sarkizova
- Broad Institute of MIT and Harvard, Cambridge, MA, USA.
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- Karthik Shekhar
- Broad Institute of MIT and Harvard, Cambridge, MA, USA.
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- James Fletcher
- Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
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- Morgane Griesbeck
- Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA, USA.
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- Andrew Butler
- New York Genome Center, New York University Center for Genomics and Systems Biology, New York, NY, USA.
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- Shiwei Zheng
- New York Genome Center, New York University Center for Genomics and Systems Biology, New York, NY, USA.
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- Suzan Lazo
- Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
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- Laura Jardine
- Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
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- David Dixon
- Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
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- Emily Stephenson
- Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
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- Emil Nilsson
- Olink Proteomics, Watertown, MA, USA.
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- Ida Grundberg
- Olink Proteomics, Watertown, MA, USA.
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- David McDonald
- Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
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- Andrew Filby
- Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
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- Weibo Li
- Broad Institute of MIT and Harvard, Cambridge, MA, USA.
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- Philip L. De Jager
- Broad Institute of MIT and Harvard, Cambridge, MA, USA.
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- Orit Rozenblatt-Rosen
- Broad Institute of MIT and Harvard, Cambridge, MA, USA.
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- Andrew A. Lane
- Broad Institute of MIT and Harvard, Cambridge, MA, USA.
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- Muzlifah Haniffa
- Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
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- Aviv Regev
- Broad Institute of MIT and Harvard, Cambridge, MA, USA.
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- Nir Hacohen
- Broad Institute of MIT and Harvard, Cambridge, MA, USA.
説明
<jats:title>What's in a drop of blood?</jats:title> <jats:p> Blood contains many types of cells, including many immune system components. Immune cells used to be characterized by marker-based assays, but now classification relies on the genes that cells express. Villani <jats:italic>et al.</jats:italic> used deep sequencing at the single-cell level and unbiased clustering to define six dendritic cell and four monocyte populations. This refined analysis has identified, among others, a previously unknown dendritic cell population that potently activates T cells. Further cell culture revealed possible differentiation progenitors within the different cell populations. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6335" page="eaah4573" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aah4573">eaah4573</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 356 (6335), eaah4573-, 2017-04-21
American Association for the Advancement of Science (AAAS)
