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- Dong Niu
- eGenesis, Cambridge, MA 02139, USA.
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- Hong-Jiang Wei
- State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
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- Lin Lin
- Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
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- Haydy George
- eGenesis, Cambridge, MA 02139, USA.
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- Tao Wang
- eGenesis, Cambridge, MA 02139, USA.
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- I-Hsiu Lee
- eGenesis, Cambridge, MA 02139, USA.
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- Hong-Ye Zhao
- State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
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- Yong Wang
- Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China.
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- Yinan Kan
- eGenesis, Cambridge, MA 02139, USA.
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- Ellen Shrock
- Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
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- Emal Lesha
- eGenesis, Cambridge, MA 02139, USA.
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- Gang Wang
- eGenesis, Cambridge, MA 02139, USA.
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- Yonglun Luo
- Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.
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- Yubo Qing
- State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
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- Deling Jiao
- State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
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- Heng Zhao
- State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China.
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- Xiaoyang Zhou
- Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China.
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- Shouqi Wang
- Research Institute of Shenzhen Jinxinnong Technology, Shenzhen 518106, China.
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- Hong Wei
- Department of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China.
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- Marc Güell
- eGenesis, Cambridge, MA 02139, USA.
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- George M. Church
- eGenesis, Cambridge, MA 02139, USA.
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- Luhan Yang
- eGenesis, Cambridge, MA 02139, USA.
説明
<jats:title>Taking the PERVs out of pigs</jats:title> <jats:p> With the severe shortage of organs needed for transplants, xenotransplantation (transplantation of nonhuman organs to humans) offers an alternative source. Some pig organs have similar size and function to those of humans. The challenge is that the pig genome harbors porcine endogenous retroviruses (PERVs) that can potentially pass to humans with possibly damaging consequences. Niu <jats:italic>et al.</jats:italic> generated pigs in which all copies of PERVs were inactivated by CRISPR-Cas9 genome engineering (see the Perspective by Denner). Not only does this work provide insights into PERV activity, but it also opens the door to a safer source of organs and tissues for pig-to-human xenotransplantation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6357" page="1303" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan4187">1303</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6357" page="1238" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aao6334">1238</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 357 (6357), 1303-1307, 2017-09-22
American Association for the Advancement of Science (AAAS)
