Profiles of advanced hepatic fibrosis evaluated by FIB‐4 index and shear wave elastography in health checkup examinees
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- Sakura Yamamura
- Division of Gastroenterology, Department of Medicine Kurume University School of Medicine Kurume Japan
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- Takumi Kawaguchi
- Division of Gastroenterology, Department of Medicine Kurume University School of Medicine Kurume Japan
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- Dan Nakano
- Division of Gastroenterology, Department of Medicine Kurume University School of Medicine Kurume Japan
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- Yoshiko Tomiyasu
- Medical Examination Section, Medical Examination Part Facilities Public Utility Foundation Saga Prefectural Health Promotion Foundation Saga Japan
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- Shinobu Yoshinaga
- Medical Examination Section, Medical Examination Part Facilities Public Utility Foundation Saga Prefectural Health Promotion Foundation Saga Japan
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- Yumi Doi
- Medical Examination Section, Medical Examination Part Facilities Public Utility Foundation Saga Prefectural Health Promotion Foundation Saga Japan
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- Hirokazu Takahashi
- Division of Metabolism and Endocrinology, Faculty of Medicine Saga University Saga Japan
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- Keizo Anzai
- Division of Metabolism and Endocrinology, Faculty of Medicine Saga University Saga Japan
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- Yuichiro Eguchi
- Division of Metabolism and Endocrinology, Faculty of Medicine Saga University Saga Japan
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- Takuji Torimura
- Division of Gastroenterology, Department of Medicine Kurume University School of Medicine Kurume Japan
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- Naoto Shiba
- Department of Orthopedics Kurume University School of Medicine Kurume Japan
Description
<jats:sec><jats:title>Aim</jats:title><jats:p>Advanced hepatic fibrosis is seen in individuals with potential hepatocellular carcinoma and cardiovascular disease. Hepatic fibrosis can be assessed using a combination of the FIB‐4 index and imaging modalities, including shear wave elastography. We aimed to investigate the prevalence of advanced fibrosis in the general population and the profiles associated with advanced fibrosis using a data‐mining analysis.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We enrolled 1155 health checkup examinees (median age 53 years, 685 women, 470 male). Advanced fibrosis was defined by FIB‐4 index ≥1.3 and liver stiffness ≥8.07 kPa using shear wave elastography. Participants were classified as normal‐mild fibrosis (<jats:italic>n</jats:italic> = 1035) or advanced fibrosis (<jats:italic>n</jats:italic> = 120). Factors associated with advanced fibrosis were analyzed by logistic regression and decision‐tree analyses.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Advanced fibrosis was observed in 10.4% of participants (120/1155). In the logistic regression analysis, independent factors for advanced fibrosis were age (≥75 years; OR 2.12, 95% CI 1.021–4.415; <jats:italic>P</jats:italic> = 0.0419) and the presence of metabolic syndrome (OR 2.51, 95% CI 1.416–4.462; <jats:italic>P</jats:italic> = 0.0017). The decision‐tree analysis showed two profiles associated with advanced fibrosis: profile 1 – individuals aged ≥65 years with metabolic syndrome and mild‐to‐moderate alcohol consumption (prevalence of advanced fibrosis 73.3%); and profile 2 – individuals without metabolic syndrome, aged ≥75 years, with no exercise habit (prevalence of advanced fibrosis 56.3%).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Advanced fibrosis was observed in 10.4% of health checkup examinees. Furthermore, we showed that aging, metabolic syndrome with mild‐to‐moderate alcohol consumption, and physical inactivity were associated with advanced fibrosis. Thus, prevention of metabolic syndrome and alcohol withdrawal, as well as exercise habits, might inhibit the progression of hepatic fibrosis.</jats:p></jats:sec>
Journal
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- Hepatology Research
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Hepatology Research 50 (2), 199-213, 2019-11-20
Wiley
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Details 詳細情報について
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- CRID
- 1363951796128227072
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- ISSN
- 1872034X
- 13866346
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- Data Source
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- Crossref