Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

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  • Ross Nortley
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
  • Nils Korte
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
  • Pablo Izquierdo
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
  • Chanawee Hirunpattarasilp
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
  • Anusha Mishra
    Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR 97239, USA.
  • Zane Jaunmuktane
    Division of Neuropathology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
  • Vasiliki Kyrargyri
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
  • Thomas Pfeiffer
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
  • Lila Khennouf
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
  • Christian Madry
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
  • Hui Gong
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
  • Angela Richard-Loendt
    Division of Neuropathology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
  • Wenhui Huang
    Molecular Physiology, CIPMM, University of Saarland, D-66421 Homburg, Germany.
  • Takashi Saito
    Laboratory for Proteolytic Neuroscience, RIKEN Centre for Brain Science, Wako, Saitama 351-0198, Japan.
  • Takaomi C. Saido
    Laboratory for Proteolytic Neuroscience, RIKEN Centre for Brain Science, Wako, Saitama 351-0198, Japan.
  • Sebastian Brandner
    Division of Neuropathology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.
  • Huma Sethi
    Division of Neurosurgery, UCL Queen Square Institute of Neurology, Queen Square, London WC1N 3BG, UK.
  • David Attwell
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.

Description

<jats:title>Pericytes put the squeeze on cognition</jats:title> <jats:p> Like a computer, the brain needs a reliable source of power, which is provided as oxygen and glucose in the blood. However, in many neurological disorders this energy supply is disrupted. Brain blood flow is controlled by adjustment of the diameters of the vessels supplying the blood. Nortley <jats:italic>et al.</jats:italic> found that, both in humans developing Alzheimer's disease (AD) and in a mouse model of AD, brain capillaries become squeezed by pericytes (see the Perspective by Liesz). By defining the underlying mechanism, they suggest potential targets for therapy in early AD. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aav9518">eaav9518</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6450" page="223" related-article-type="in-this-issue" vol="365" xlink:href="10.1126/science.aay2720">223</jats:related-article> </jats:p>

Journal

  • Science

    Science 365 (6450), eaav9518-, 2019-07-19

    American Association for the Advancement of Science (AAAS)

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