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- Claire Magnon
- Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
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- Simon J. Hall
- Department of Urology, Mount Sinai School of Medicine, New York, NY 10029, USA.
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- Juan Lin
- Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
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- Xiaonan Xue
- Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
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- Leah Gerber
- Department of Surgery, Durham VA Medical Center, Durham, NC 27705, USA.
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- Stephen J. Freedland
- Department of Surgery, Durham VA Medical Center, Durham, NC 27705, USA.
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- Paul S. Frenette
- Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
説明
<jats:title>Cancer Hits a Nerve</jats:title> <jats:p> Solid tumors sculpt their microenvironment to maximize their growth and metastatic potential. This concept is illustrated most famously by tumor angiogenesis, a process whereby tumors induce the growth of new blood vessels to boost their supply of oxygen and blood-borne nutrients. <jats:bold> Magnon <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1236361">10.1126/science.1236361</jats:related-article> ; see the Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6142" page="134" related-article-type="in-this-issue" vol="341" xlink:href="10.1126/science.1241776">Isaacs</jats:related-article> </jats:bold> ) now highlight the important contribution made by another microenvironmental component—developing autonomic nerve fibers—to tumor growth and metastasis. In mouse models of prostate cancer, surgical or chemical destruction of sympathetic nerves prevented early-stage growth of tumors, whereas pharmacological inhibition of parasympathetic nerves inhibited tumor dissemination. In a small study of human prostate cancer specimens, the presence of a high density of nerve fibers in and around the tumor tissue was found to correlate with poor clinical outcome. These results raise the possibility that drugs targeting the autonomic nervous system may have therapeutic potential for prostate cancer. </jats:p>
収録刊行物
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- Science
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Science 341 (6142), 1236361-, 2013-07-12
American Association for the Advancement of Science (AAAS)