Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles

DOI Web Site 3 Citations
  • Velislava N. Petrova
    Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.
  • Bevan Sawatsky
    Veterinary Medicine Division, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines and DZIF TTU Emerging Infections, Langen, Germany.
  • Alvin X. Han
    Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
  • Brigitta M. Laksono
    Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands.
  • Lisa Walz
    Veterinary Medicine Division, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines and DZIF TTU Emerging Infections, Langen, Germany.
  • Edyth Parker
    Laboratory of Applied Evolutionary Biology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
  • Kathrin Pieper
    Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland.
  • Carl A. Anderson
    Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.
  • Rory D. de Vries
    Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands.
  • Antonio Lanzavecchia
    Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland.
  • Paul Kellam
    Department of Medicine, Division of Infectious Diseases, Imperial College Faculty of Medicine, Wright Fleming Institute, St Mary’s Campus, London, UK.
  • Veronika von Messling
    Veterinary Medicine Division, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines and DZIF TTU Emerging Infections, Langen, Germany.
  • Rik L. de Swart
    Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands.
  • Colin A. Russell
    Laboratory of Applied Evolutionary Biology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.

Description

<jats:p>Measles causes immunosuppression by restricting naïve B cell diversity and eliminating previously established B memory cells.</jats:p>

Journal

  • Science Immunology

    Science Immunology 4 (41), aay6125-, 2019-11

    American Association for the Advancement of Science (AAAS)

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