Activity‐Based NIR Enzyme Fluorescent Probes for the Diagnosis of Tumors and Image‐Guided Surgery

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  • Haidong Li
    Department of Chemistry and Nanoscience Ewha Womans University Seoul 03760 Korea
  • Dayeh Kim
    Department of Chemistry and Nanoscience Ewha Womans University Seoul 03760 Korea
  • Qichao Yao
    State Key Laboratory of Fine Chemicals Dalian University of Technology 2 Linggong Road, Hi-tech Zone Dalian 116024 China
  • Haoying Ge
    State Key Laboratory of Fine Chemicals Dalian University of Technology 2 Linggong Road, Hi-tech Zone Dalian 116024 China
  • Jeewon Chung
    Department of Chemistry and Nanoscience Ewha Womans University Seoul 03760 Korea
  • Jiangli Fan
    State Key Laboratory of Fine Chemicals Dalian University of Technology 2 Linggong Road, Hi-tech Zone Dalian 116024 China
  • Jingyun Wang
    School of Bioengineering Dalian University of Technology 2 Linggong Road, Hi-tech Zone Dalian 116024 China
  • Xiaojun Peng
    State Key Laboratory of Fine Chemicals Dalian University of Technology 2 Linggong Road, Hi-tech Zone Dalian 116024 China
  • Juyoung Yoon
    Department of Chemistry and Nanoscience Ewha Womans University Seoul 03760 Korea

Abstract

<jats:title>Abstract</jats:title><jats:p>Near‐infrared (NIR) activatable fluorescent probes have been considered to be the effective edge tools for the investigation of cell biology and disease diagnosis because of their outstanding advantages. Related genes involved in tumor genesis and progression regulate the overexpression of certain enzymes. Owing to the distinctive characteristics of quick reaction time and favorable pharmacokinetics, enzyme‐reactive NIR optical probes have shown great potential in the diagnosis of tumorigenesis and in image‐guided intraoperative surgeries with high signal‐to‐noise ratios. In this review, we mainly summarize the latest advancements in enzyme‐reactive NIR fluorescent probes from design strategy to biomedical application. Specifically, some challenges and prospects in this field are presented at the end of the review, which will be beneficial to innovatively construct new multifunctional fluorescent probes and actively promote their clinical transformation in the future.</jats:p>

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