Interaction of <i>Porphyromonas gingivalis with gingival</i> epithelial cells maintained in culture.

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<jats:p>Interactions between <jats:italic>Porphyromonas gingivalis</jats:italic> and gingival epithelial cells were investigated. Gingival epithelial cells were cultured from surgically removed gingival tissue. Electron microscopy demonstrated adherence of <jats:italic>P. gingivalis</jats:italic> to the cell membranes and microvilli followed by internalization of the bacteria into the epithelial cell cytoplasm. Saliva from healthy and periodontally diseased patients inhibited <jats:italic>P. gingivalis</jats:italic> association with the epithelial cells. Attachment to and penetration of gingival epithelial cells by <jats:italic>P. gingivalis</jats:italic> may be important virulence factors in periodontal disease. Salivary molecules may play a role in modulating these interactions.</jats:p>

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