Regulation of EBV LMP1-triggered EphA4 downregulation in EBV-associated B lymphoma and its impact on patients’ survival
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- Ya-Chi Huang
- Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan;
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- Sue-Jane Lin
- Research Center for Emerging Viral Infections and
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- Kai-Min Lin
- Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan;
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- Ya-Ching Chou
- Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan;
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- Chung-Wu Lin
- Department of Pathology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan;
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- Shan-Chi Yu
- Department of Pathology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan;
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- Chi-Long Chen
- Department of Pathology, College of Medicine, Taipei Medical University, Taipei, Taiwan;
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- Tang-Long Shen
- Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan;
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- Chi-Kuan Chen
- Genomics Research Center, Academia Sinica, Taipei, Taiwan; and
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- Jean Lu
- Genomics Research Center, Academia Sinica, Taipei, Taiwan; and
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- Mei-Ru Chen
- Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan;
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- Ching-Hwa Tsai
- Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan;
抄録
<jats:title>Key Points</jats:title> <jats:p>EBV LMP1 dysregulates EphA4 expression via the ERK-Sp1 pathway. Downregulation of EphA4 is demonstrated in EBV+ DLBCL, which is significantly correlated with poor DLBCL survival.</jats:p>
収録刊行物
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- Blood
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Blood 128 (12), 1578-1589, 2016-09-22
American Society of Hematology