Absorption and excretion of orally administered inositol hexaphosphate (IP<sub>6</sub> or phytate) in humans

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<jats:title>Abstract</jats:title><jats:p>A study of the pharmacokinetic profile (oral absorption and renal excretion) of inositol hexaphosphate or phytate (IP<jats:sub>6</jats:sub>) is presented. Seven healthy volunteers were following a IP<jats:sub>6</jats:sub> poor diet (IP<jats:sub>6</jats:sub>PD) in a first period, and on IP<jats:sub>6</jats:sub> normal diet (IP<jats:sub>6</jats:sub>ND) in a second one. When following the IP<jats:sub>6</jats:sub>PD they become deficient in IP<jats:sub>6</jats:sub>, the basal levels found in plasma (0.07± 0.01 mg/L) being clearly lower than those found when IP<jats:sub>6</jats:sub>ND was consumed (0.26± 0.03 mg/L). During the restriction period the maximum concentration in plasma were obtained 4 h after the ingestion of a single dose of IP<jats:sub>6</jats:sub>, observing almost the same renal excretion profiles for the three different comercial sources and doses. After the IP<jats:sub>6</jats:sub> restriction period, volunteers were on IP<jats:sub>6</jats:sub>ND, reaching normal plasma and urinary IP<jats:sub>6</jats:sub> values in 16 days. Thus, the normal plasma and urinary concentrations, can be obtained either by comsumption of a IP<jats:sub>6</jats:sub>ND taking a long time or in a short period by IP<jats:sub>6</jats:sub> supplements.</jats:p>

収録刊行物

  • BioFactors

    BioFactors 15 (1), 53-61, 2001-01

    Wiley

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