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- Jeffrey S. Thompson
- Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.
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- Sarah A. Bixler
- Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.
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- Fang Qian
- Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.
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- Kalpit Vora
- Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.
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- Martin L. Scott
- Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.
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- Teresa G. Cachero
- Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.
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- Catherine Hession
- Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.
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- Pascal Schneider
- The Institute of Biochemistry, University of Lausanne, CH-1066, Epalinges, Switzerland.
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- Irene D. Sizing
- Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.
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- Colleen Mullen
- Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.
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- Kathy Strauch
- Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.
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- Mohammad Zafari
- Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.
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- Christopher D. Benjamin
- Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.
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- Jurg Tschopp
- The Institute of Biochemistry, University of Lausanne, CH-1066, Epalinges, Switzerland.
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- Jeffrey L. Browning
- Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.
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- Christine Ambrose
- Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA.
書誌事項
- 公開日
- 2001-09-14
- DOI
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- 10.1126/science.1061965
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:p>B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival.</jats:p>
収録刊行物
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- Science
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Science 293 (5537), 2108-2111, 2001-09-14
American Association for the Advancement of Science (AAAS)
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詳細情報 詳細情報について
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- CRID
- 1364233268382391040
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- NII論文ID
- 80012643141
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- ISSN
- 10959203
- 00368075
- http://id.crossref.org/issn/00368075
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- データソース種別
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- Crossref
- CiNii Articles