Nuclear Factor κB Signaling in Atherogenesis

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  • Menno P.J. de Winther
    From the Department of Molecular Genetics (M.P.J.d.W., M.H.H.), Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands; and the Department of Molecular Cell Biology and Immunology (E.K., G.K.), VU Medical Center, Amsterdam, The Netherlands.
  • Edwin Kanters
    From the Department of Molecular Genetics (M.P.J.d.W., M.H.H.), Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands; and the Department of Molecular Cell Biology and Immunology (E.K., G.K.), VU Medical Center, Amsterdam, The Netherlands.
  • Georg Kraal
    From the Department of Molecular Genetics (M.P.J.d.W., M.H.H.), Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands; and the Department of Molecular Cell Biology and Immunology (E.K., G.K.), VU Medical Center, Amsterdam, The Netherlands.
  • Marten H. Hofker
    From the Department of Molecular Genetics (M.P.J.d.W., M.H.H.), Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands; and the Department of Molecular Cell Biology and Immunology (E.K., G.K.), VU Medical Center, Amsterdam, The Netherlands.
  • Moleculaire Celbiologie
  • Moleculaire Genetica
  • RS: NUTRIM School of Nutrition and Translational Research in Metabolism
  • RS: CARIM School for Cardiovascular Diseases
  • VU University medical center

説明

<jats:p>Atherosclerosis is an inflammatory disease, characterized by the accumulation of macrophage-derived foam cells in the vessel wall and accompanied by the production of a wide range of chemokines, cytokines, and growth factors. These factors regulate the turnover and differentiation of immigrating and resident cells, eventually influencing plaque development. One of the key regulators of inflammation is the transcription factor nuclear factor κB (NF-κB), which, for a long time, has been regarded as a proatherogenic factor, mainly because of its regulation of many of the proinflammatory genes linked to atherosclerosis. NF-κB may play an important role in guarding the delicate balance of the atherosclerotic process as a direct regulator of proinflammatory and anti-inflammatory genes and as a regulator of cell survival and proliferation. Here we address recent literature on the function of NF-κB in inflammatory responses and its relation to atherosclerosis.</jats:p>

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