Lactate in the brain: an update on its relevance to brain energy, neurons, glia and panic disorder
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- Laurel Riske
- Department of Psychiatry, University of Alberta, Edmonton, AB, Canada
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- Rejish K. Thomas
- Department of Psychiatry, University of Alberta, Edmonton, AB, Canada
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- Glen B. Baker
- Department of Psychiatry, University of Alberta, Edmonton, AB, Canada
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- Serdar M. Dursun
- Department of Psychiatry (Neurochemical Research Unit, NRU), 12th Floor, Clinical Science Building, University of Alberta, Edmonton, AB, T6G 2G3, Canada
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説明
<jats:p> Lactate is considered an important metabolite in the human body, but there has been considerable debate about its roles in brain function. Research in recent years has suggested that lactate from astrocytes may be crucial for supporting axonal function, especially during times of high metabolic demands or hypoglycemia. The astrocyte-neuron lactate transfer shuttle system serves a protective function to ensure a supply of substrates for brain metabolism, and oligodendrocytes appear to also influence availability of lactate. There is increasing evidence for lactate acting as a signaling molecule in the brain to link metabolism, substrate availability, blood flow and neuronal activity. This review will attempt to connect evidence to the relationship lactate has to panic disorder (PD), which suggests that its transporters, receptors or metabolism warrant investigation as potential therapeutic targets in PD. </jats:p>
収録刊行物
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- Therapeutic Advances in Psychopharmacology
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Therapeutic Advances in Psychopharmacology 7 (2), 85-89, 2016-10-28
SAGE Publications
