Prognostic and therapeutic implications of minimal residual disease detection in acute myeloid leukemia
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- Francesco Buccisano
- Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy;
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- Luca Maurillo
- Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy;
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- Maria Ilaria Del Principe
- Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy;
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- Giovanni Del Poeta
- Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy;
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- Giuseppe Sconocchia
- Institute of Translational Pharmacology, Department of Medicine, CNR, Rome, Italy; and
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- Francesco Lo-Coco
- Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy;
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- William Arcese
- Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy;
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- Sergio Amadori
- Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy;
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- Adriano Venditti
- Hematology, Fondazione Policlinico Tor Vergata, Rome, Italy;
Description
<jats:p>The choice of either induction or postremission therapy for adults with acute myeloid leukemia is still largely based on the “one size fits all” principle. Moreover, pretreatment prognostic parameters, especially chromosome and gene abnormalities, may fail in predicting individual patient outcome. Measurement of minimal residual disease (MRD) is nowadays recognized as a potential critical tool to assess the quality of response after chemotherapy and to plan postremission strategies that are, therefore, driven by the individual risk of relapse. PCR and multiparametric flow cytometry have become the most popular methods to investigate MRD because they have been established as sensitive and specific enough to allow MRD to be studied serially. In the present review, we examine the evidence supporting the appropriateness of incorporating MRD detection into the AML risk assessment process. A comprehensive prognostic algorithm, generated by combining pretreatment cytogenetics/genetics and posttreatment MRD determination, should promote advances in development of personalized therapeutic approaches.</jats:p>
Journal
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- Blood
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Blood 119 (2), 332-341, 2012-01-12
American Society of Hematology
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Details 詳細情報について
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- CRID
- 1364233268503536640
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- ISSN
- 15280020
- 00064971
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- Data Source
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- Crossref