Paintable and Rapidly Bondable Conductive Hydrogels as Therapeutic Cardiac Patches
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- Shuang Liang
- School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300072 China
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- Yinyu Zhang
- School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300072 China
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- Hongbo Wang
- School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300072 China
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- Ziyang Xu
- School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300072 China
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- Jingrui Chen
- Research Center of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin 300193 P. R. China
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- Rui Bao
- School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300072 China
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- Baoyu Tan
- School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300072 China
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- Yuanlu Cui
- Research Center of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin 300193 P. R. China
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- Guanwei Fan
- Research Center of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin 300193 P. R. China
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- Wenxin Wang
- School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300072 China
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- Wei Wang
- School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300072 China
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- Wenguang Liu
- School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300072 China
説明
<jats:title>Abstract</jats:title><jats:p>In recent years, cardiac patches have been developed for the treatment of myocardial infarction. However, the fixation approaches onto the tissue through suture or phototriggered reaction inevitably cause new tissue damage. Herein, a paintable hydrogel is constructed based on Fe<jats:sup>3+</jats:sup>‐triggered simultaneous polymerization of covalently linked pyrrole and dopamine in the hyperbranched chains where the in situ formed conductive polypyrrole also uniquely serves to crosslink network. This conductive and adhesive hydrogel can be conveniently painted as a patch onto the heart surface without adverse liquid leakage. The functional patch whose conductivity is equivalent to that of normal myocardium is strongly bonded to the beating heart within 4 weeks, accordingly efficiently boosting the transmission of electrophysiological signals. Eventually, the reconstruction of cardiac function and revascularization of the infarct myocardium are remarkably improved. The translatable suture‐free strategy reported in this work is promising to address the human clinical challenges in cardiac tissue engineering.</jats:p>
収録刊行物
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- Advanced Materials
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Advanced Materials 30 (23), 2018-04-24
Wiley
