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- Guem Hee Baek
- Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
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- Haili Cheng
- Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
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- Vitnary Choe
- Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
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- Xin Bao
- Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
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- Jia Shao
- The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330006, China
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- Shiwen Luo
- The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330006, China
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- Hai Rao
- Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
説明
<jats:p>Cdc48 (also called VCP and p97) is an abundant protein that plays essential regulatory functions in a broad array of cellular processes. Working with various cofactors, Cdc48 utilizes its ATPase activity to promote the assembly and disassembly of protein complexes. Here, we review key biological functions and regulation of Cdc48 in ubiquitin-related events. Given the broad employment of Cdc48 in cell biology and its intimate ties to human diseases (e.g., amyotrophic lateral sclerosis), studies of Cdc48 will bring significant insights into the mechanism and function of ubiquitin in health and diseases.</jats:p>
収録刊行物
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- Journal of Amino Acids
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Journal of Amino Acids 2013 1-12, 2013-09-15
Hindawi Limited
