A Neural Tetraspanin, Encoded by <i>late bloomer</i> , That Facilitates Synapse Formation
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- Casey C. Kopczynski
- Howard Hughes Medical Institute, Neurobiology Division, Department of Molecular and Cell Biology, 519 Life Sciences Addition, University of California, Berkeley, CA 94720, USA.
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- Graeme W. Davis
- Howard Hughes Medical Institute, Neurobiology Division, Department of Molecular and Cell Biology, 519 Life Sciences Addition, University of California, Berkeley, CA 94720, USA.
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- Corey S. Goodman
- Howard Hughes Medical Institute, Neurobiology Division, Department of Molecular and Cell Biology, 519 Life Sciences Addition, University of California, Berkeley, CA 94720, USA.
説明
<jats:p> Upon contacting its postsynaptic target, a neuronal growth cone transforms into a presynaptic terminal. A membrane component on the growth cone that facilitates synapse formation was identified by means of a complementary DNA-based screen followed by genetic analysis. The <jats:italic>late bloomer</jats:italic> ( <jats:italic>lbl</jats:italic> ) gene in <jats:italic>Drosophila</jats:italic> encodes a member of the tetraspanin family of cell surface proteins. LBL protein is transiently expressed on motor axons, growth cones, and terminal arbors. In <jats:italic>lbl</jats:italic> mutant embryos, the growth cone of the RP3 motoneuron contacts its target muscles, but synapse formation is delayed and neighboring motoneurons display an increase in ectopic sprouting. </jats:p>
収録刊行物
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- Science
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Science 271 (5257), 1867-1870, 1996-03-29
American Association for the Advancement of Science (AAAS)