The Effect of Piperidine and Allied Substances on Mammalian Skeletal Muscle

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<jats:title>Summary.</jats:title><jats:p> <jats:list list-type="explicit-label"> <jats:list-item><jats:p> Piperidine in doses of 50 μg or more produces a short tetanus in the tibialis anterior of the cat, when applied <jats:italic>ad modum</jats:italic> BROWN (1938), <jats:italic>i. e.</jats:italic>, “close arterial injection”.</jats:p></jats:list-item> <jats:list-item><jats:p> The effect of subsequent maximal single twitches is either a transient potentiation or else inhibition (the latter sometimes reversible).</jats:p></jats:list-item> <jats:list-item><jats:p> The myogram of piperidine has a slower rise and fall than the corresponding acetylcholine curve.</jats:p></jats:list-item> <jats:list-item><jats:p> Denervated muscle is highly sensitive to piperidine. It causes contraction and, in larger doses, contracture.</jats:p></jats:list-item> <jats:list-item><jats:p> Injection of Locke's solution, plasma, or some other physiological solution may sometimes produce a short tetanus (“Injection effect”).</jats:p></jats:list-item> <jats:list-item><jats:p> Nicotine and coniine give contraction and subsequent inhibition of indirectly induced contractions.</jats:p></jats:list-item> <jats:list-item><jats:p> Spartein and arecoline give slight or no contraction, but distinct inhibition of indirectly induced contractions.</jats:p></jats:list-item> </jats:list> </jats:p>

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