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- AK Stewart
- Division of Hematology-Oncology, Toronto Hospital, Ontario, Canada.
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- RS Schwartz
- Division of Hematology-Oncology, Toronto Hospital, Ontario, Canada.
書誌事項
- 公開日
- 1994-04-01
- DOI
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- 10.1182/blood.v83.7.1717.1717
- 公開者
- American Society of Hematology
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>There is now substantial evidence that a small group of V genes predominates in the Ig repertoire of preimmune B cells. This phenomenon of V gene restriction may reflect preferential accessibility of these genes to recombinase, homology-directed V gene rearrangement, promoters and enhances of V gene transcription, or positive and negative selection mediated by the anti-self binding properties of the B cells surface Ig. These mechanisms may operate alone or in combination to influence V gene rearrangement and populations of immature B cells. Although constraints on the pool of rearranged V genes may seem disadvantageous to the immune system, the mechanisms that generate the CDR3s of heavy and light chains ensure extensive diversity in the pre-B- cell population. In mature B cells, somatic mutation of V genes adds further diversity. CDR3 sequences and somatic mutations not only provide potentially useful clonal markers but also help to identify the normal counterparts of malignant B cells.</jats:p>
収録刊行物
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- Blood
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Blood 83 (7), 1717-1730, 1994-04-01
American Society of Hematology