A survey of fertility and sexual health following allogeneic haematopoietic stem cell transplantation in New South Wales, Australia
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- Gemma Dyer
- Northern Clinical School Faculty of Medicine University of Sydney Sydney NSW Australia
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- Nicole Gilroy
- Blood and Marrow Transplant Network New South Wales Agency for Clinical Innovation Sydney NSW Australia
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- Jennifer Bradford
- Department of Obstetrics & Gynaecology Westmead Hospital Sydney NSW Australia
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- Lisa Brice
- Department of Haematology Royal North Shore Hospital Sydney NSW Australia
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- Masura Kabir
- Westmead Breast Cancer Institute Sydney NSW Australia
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- Matt Greenwood
- Northern Clinical School Faculty of Medicine University of Sydney Sydney NSW Australia
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- Stephen R. Larsen
- Institute of Haematology Royal Prince Alfred Hospital Sydney NSW Australia
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- John Moore
- Department of Haematology St Vincent Hospital Sydney NSW Australia
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- Mark Hertzberg
- Department of Haematology Prince of Wales Hospital Sydney NSW Australia
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- John Kwan
- Department of Haematology Westmead Hospital Sydney NSW Australia
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- Louisa Brown
- Department of Haematology Newcastle Mater Hospital Sydney NSW Australia
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- Megan Hogg
- Department of Haematology Westmead Hospital Sydney NSW Australia
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- Gillian Huang
- Department of Haematology Westmead Hospital Sydney NSW Australia
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- Jeff Tan
- Department of Haematology St Vincent Hospital Sydney NSW Australia
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- Christopher Ward
- Northern Clinical School Faculty of Medicine University of Sydney Sydney NSW Australia
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- Ian Kerridge
- Northern Clinical School Faculty of Medicine University of Sydney Sydney NSW Australia
抄録
<jats:title>Summary</jats:title><jats:p>Four hundred and twenty‐one adult allogeneic haematopoietic stem cell transplant (<jats:styled-content style="fixed-case">HSCT</jats:styled-content>) survivors participated in a cross‐sectional study to assess sexual dysfunction and infertility post‐transplant. Survey instruments included the Sydney Post‐Blood and Marrow Transplant (<jats:styled-content style="fixed-case">BMT</jats:styled-content>) Survey, Functional Assessment of Cancer Treatment (<jats:styled-content style="fixed-case">FACT</jats:styled-content>) – BMT, the Depression, Anxiety, Stress Scales (<jats:styled-content style="fixed-case">DASS</jats:styled-content> 21), the Chronic Graft‐versus‐Host Disease (<jats:styled-content style="fixed-case">cGVHD</jats:styled-content>) Activity Assessment‐ Patient Self Report (Form B), the Lee <jats:styled-content style="fixed-case">cGVHD</jats:styled-content> Symptom Scale and The Post‐Traumatic Growth Inventory. Most HSCT survivors reported sexual difficulties (51% of males; 66% of females). Men reported erectile dysfunction (79%) and decreased libido (61·6%) and women reported loss of libido (83%), painful intercourse (73%) and less enjoyment of sex (68%). Women also commonly reported vaginal dryness (73%), vaginal narrowing (34%) and vaginal irritation (26%). Woman had much higher rates of genital cGvHD than men (22% vs. 5%). Age and <jats:styled-content style="fixed-case">cGVHD</jats:styled-content> were significantly associated with sexual dysfunction. Few survivors had children following transplant (3·3%). However, for those of reproductive age at <jats:styled-content style="fixed-case">HSCT</jats:styled-content>, 22% reported trying to conceive, with 10·3% reporting success. This study is the largest to date exploring sexual function in survivors of allo‐<jats:styled-content style="fixed-case">HSCT</jats:styled-content>. This data provides the basis for health service reform to better meet the needs of <jats:styled-content style="fixed-case">HSCT</jats:styled-content> survivors, including evidence to support counselling and education both pre‐ and post‐transplant.</jats:p>
収録刊行物
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- British Journal of Haematology
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British Journal of Haematology 172 (4), 592-601, 2015-12-21
Wiley