Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort
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- David J. Hughes
- Department of Physiology & Medical Physics & Centre for Systems Medicine Royal College of Surgeons in Ireland 31A York Street Dublin 2 Ireland
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- Veronika Fedirko
- Department of Epidemiology Rollins School of Public Health, Winship Cancer Institute, Emory University Atlanta GA
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- Mazda Jenab
- Section of Nutrition & Metabolism International Agency for Research on Cancer 150 Cours Albert Thomas Lyon Cedex 08 France
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- Lutz Schomburg
- Institut für Experimentelle Endokrinologie, Charité ‐ Universitätsmedizin Berlin CVK, Südring 10 D‐13353 Berlin Germany
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- Catherine Méplan
- Institute for Cell and Molecular Biosciences and Human Nutrition Research Centre, Newcastle University, Newcastle‐upon‐Tyne NE2 4HH United Kingdom
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- Heinz Freisling
- Section of Nutrition & Metabolism International Agency for Research on Cancer 150 Cours Albert Thomas Lyon Cedex 08 France
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- H.B(as) Bueno‐de‐Mesquita
- Department for Determinants of Chronic Diseases National Institute for Public Health and the Environment (RIVM) Bilthoven The Netherlands
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- Sandra Hybsier
- Institut für Experimentelle Endokrinologie, Charité ‐ Universitätsmedizin Berlin CVK, Südring 10 D‐13353 Berlin Germany
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- Niels‐Peter Becker
- Institut für Experimentelle Endokrinologie, Charité ‐ Universitätsmedizin Berlin CVK, Südring 10 D‐13353 Berlin Germany
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- Magdalena Czuban
- Institut für Experimentelle Endokrinologie, Charité ‐ Universitätsmedizin Berlin CVK, Südring 10 D‐13353 Berlin Germany
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- Anne Tjønneland
- Diet, Genes and Environment Danish Cancer Society Research Center Strandboulevarden 49 DK 2100 Copenhagen Denmark
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- Malene Outzen
- Diet, Genes and Environment Danish Cancer Society Research Center Strandboulevarden 49 DK 2100 Copenhagen Denmark
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- Marie‐Christine Boutron‐Ruault
- Centre for Research in Epidemiology and Population Health (CESP), Inserm U1018, Nutrition, Hormones and Women's Health team F‐94805 Villejuif France
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- Antoine Racine
- Centre for Research in Epidemiology and Population Health (CESP), Inserm U1018, Nutrition, Hormones and Women's Health team F‐94805 Villejuif France
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- Nadia Bastide
- Centre for Research in Epidemiology and Population Health (CESP), Inserm U1018, Nutrition, Hormones and Women's Health team F‐94805 Villejuif France
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- Tilman Kühn
- Department of Cancer Epidemiology German Cancer Research Center (DKFZ) Heidelberg Germany
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- Rudolf Kaaks
- Department of Cancer Epidemiology German Cancer Research Center (DKFZ) Heidelberg Germany
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- Dimitrios Trichopoulos
- Department of Epidemiology Harvard School of Public Health 677 Huntington Avenue Boston MA
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- Antonia Trichopoulou
- Bureau of Epidemiologic Research Academy of Athens, 23 Alexandroupoleos Street, Athens GR‐115 27 Greece
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- Pagona Lagiou
- Department of Epidemiology Harvard School of Public Health 677 Huntington Avenue Boston MA
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- Salvatore Panico
- Department of Clinical and Experimental Medicine Federico II University Naples Italy
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- Petra H Peeters
- Department of Epidemiology and Biostatistics The School of Public Health, Imperial College London London United Kingdom
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- Elisabete Weiderpass
- Department of Community Medicine, Faculty of Health Sciences University of Tromsø Tromsø Norway
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- Guri Skeie
- Department of Community Medicine, Faculty of Health Sciences University of Tromsø Tromsø Norway
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- Engeset Dagrun
- Department of Community Medicine, Faculty of Health Sciences University of Tromsø Tromsø Norway
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- Maria‐Dolores Chirlaque
- Department of Epidemiology Murcia Regional Health Authority Spain
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- Maria‐Jose Sánchez
- CIBER Epidemiology and Public Health CIBERESP Spain
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- Eva Ardanaz
- CIBER Epidemiology and Public Health CIBERESP Spain
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- Ingrid Ljuslinder
- Department of Oncology Umeå University Umeå Sweden
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- Maria Wennberg
- Public Health and Clinical Medicine Nutritional Research, Umeå University Umeå Sweden
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- Kathryn E Bradbury
- Nuffield Department of Population Health Cancer Epidemiology Unit, University of Oxford Oxford OX3 7LF United Kingdom
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- Paolo Vineis
- Department of Epidemiology and Biostatistics The School of Public Health, Imperial College London London United Kingdom
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- Alessio Naccarati
- Molecular and Genetic Epidemiology Unit HuGeF ‐ Human Genetics Foundation Via Nizza 52 ‐ 10126 Torino Italy
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- Domenico Palli
- Molecular and Nutritional Epidemiology Unit Cancer Research and Prevention Institute, ISPO Florence Italy
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- Heiner Boeing
- Department of Epidemiology German Institute of Human Nutrition Potsdam‐Rehbruecke Nuthetal Germany
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- Kim Overvad
- Department of Public Health, Section for Epidemiology Aarhus University Aarhus Denmark
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- Miren Dorronsoro
- Health Division of Gipuzkoa, BioDonostia Research Institute Donostia Spain
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- Paula Jakszyn
- Catalan Institute of Oncology (ICO) Barcelona Spain
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- Amanda J. Cross
- Department of Epidemiology and Biostatistics The School of Public Health, Imperial College London London United Kingdom
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- Jose Ramón Quirós
- Public Health Directorate of Asturias Oviedo Spain
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- Magdalena Stepien
- Section of Nutrition & Metabolism International Agency for Research on Cancer 150 Cours Albert Thomas Lyon Cedex 08 France
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- So Yeon Kong
- Section of Nutrition & Metabolism International Agency for Research on Cancer 150 Cours Albert Thomas Lyon Cedex 08 France
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- Talita Duarte‐Salles
- Section of Nutrition & Metabolism International Agency for Research on Cancer 150 Cours Albert Thomas Lyon Cedex 08 France
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- Elio Riboli
- Department of Epidemiology and Biostatistics The School of Public Health, Imperial College London London United Kingdom
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- John E. Hesketh
- Institute for Cell and Molecular Biosciences and Human Nutrition Research Centre, Newcastle University, Newcastle‐upon‐Tyne NE2 4HH United Kingdom
説明
<jats:p>Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring serum levels of Se and Selenoprotein P (SePP) and examined the association with CRC risk in a nested case–control design (966 CRC cases; 966 matched controls) within the European Prospective Investigation into Cancer and Nutrition. Se was measured by total reflection X‐ray fluorescence and SePP by immunoluminometric sandwich assay. Multivariable incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Respective mean Se and SePP levels were 84.0 μg/L and 4.3 mg/L in cases and 85.6 μg/L and 4.4 mg/L in controls. Higher Se concentrations were associated with a non‐significant lower CRC risk (IRR = 0.92, 95% CI: 0.82–1.03 per 25 μg/L increase). However, sub‐group analyses by sex showed a statistically significant association for women (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.032; per 25 μg/L Se increase, IRR = 0.83, 95% CI: 0.70–0.97) but not for men. Higher SePP concentrations were inversely associated with CRC risk (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.009; per 0.806 mg/L increase, IRR = 0.89, 95% CI: 0.82–0.98) with the association more apparent in women (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.004; IRR = 0.82, 95% CI: 0.72–0.94 per 0.806 mg/L increase) than men (<jats:italic>p</jats:italic><jats:sub>trend</jats:sub> = 0.485; IRR = 0.98, 95% CI: 0.86–1.12 per 0.806 mg/L increase). The findings indicate that Se status is suboptimal in many Europeans and suggest an inverse association between CRC risk and higher serum Se status, which is more evident in women.</jats:p>
収録刊行物
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- International Journal of Cancer
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International Journal of Cancer 136 (5), 1149-1161, 2014-07-21
Wiley