書誌事項
- 公開日
- 1992-02
- 権利情報
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- http://www.springer.com/tdm
- DOI
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- 10.1007/bf01209657
- 公開者
- Springer Science and Business Media LLC
この論文をさがす
説明
p53 point mutations in primary gastric carcinomas were analyzed by performing cDNA deoxynucleotide sequencing of the gene. Out of 16, 9 (56.3%) primary gastric carcinoma cases, including early cancer, showed one or more p53 point mutations in their open-reading frame, and 4 out of 9 cases had a p53 point mutation within highly conserved domains. The characteristics of the p53 mutation spectrum observed in primary tumors were (a) frequent mutation at an A:T pair (50%, 7 out of 14 mutations), (b) high transversion incidence (29%, 4 out of 14 mutations), (c) no transition at CpG, and (d) no G:C to T:A transversion. Our results suggest that p53 mutation is a common event in gastric carcinoma occurring from the early stage of progression with its specific mutation spectrum.
収録刊行物
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- Journal of Cancer Research and Clinical Oncology
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Journal of Cancer Research and Clinical Oncology 119 (2), 67-70, 1992-02
Springer Science and Business Media LLC