Salicylic Acid-grafted Chitosan Oligosaccharide Nanoparticle for Paclitaxel Delivery
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- Xiao-Hong Wei
- College of Pharmaceutical Science, Zhejiang University Hangzhou, 310058, P. R. China,
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- Yang-Ping Niu
- College of Pharmaceutical Science, Zhejiang University of Technology Hangzhou, 310032, P. R. China
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- Yang-Yan Xu
- College of Pharmaceutical Science, Zhejiang University Hangzhou, 310058, P. R. China, College of Pharmaceutical Science, Zhejiang University of Technology Hangzhou, 310032, P. R. China
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- Yong-Zhong Du
- College of Pharmaceutical Science, Zhejiang University Hangzhou, 310058, P. R. China
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- Fu-Qiang Hu
- College of Pharmaceutical Science, Zhejiang University Hangzhou, 310058, P. R. China
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- Hong Yuan
- College of Pharmaceutical Science, Zhejiang University Hangzhou, 310058, P. R. China
説明
<jats:p> A hydrotropic agent, salicylic acid (SA), was grafted to chitosan oligosaccharide (CSO) backbone to develop a CSO/SA conjugate. The CSO/SA self-assembled to form nanoparticles (NPs) in aqueous medium. The sizes of the NPs were smaller as more SA was grafted and when lower molecular weight CSO was used. The ζ-potentials of all CSO/SA NPs were above 40 mV. The critical aggregation concentrations of NPs decreased from 454.79 to 164.0 μg/mL by increasing the grafted SA content or the CSO Mw. Paclitaxel (PTX)-loaded NPs were prepared by a dialysis method; the particle sizes and ζ-potentials were smaller than the blank NPs. A series of PTX-loaded CSO<jats:sub>28,000</jats:sub>/SA<jats:sub>50%</jats:sub> NPs were prepared; as the size decreased or the drug content increased, the in vitro release rate increased. The in vitro cytotoxicity of blank CSO/SA NPs was determined using the MCF-7 cell line. The CSO/SA provides a new means of making a stable delivery for PTX. </jats:p>
収録刊行物
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- Journal of Bioactive and Compatible Polymers
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Journal of Bioactive and Compatible Polymers 25 (3), 319-335, 2010-03-03
SAGE Publications
