Antigen Presentation and T Cell Stimulation by Dendritic Cells

DOI Web Site 被引用文献34件
  • Pierre Guermonprez
    Institut Curie, INSERM U520, 12 rue Lhomond, 75005 Paris, France, U520, Institut Curie;, , ,
  • Jenny Valladeau
    Institut Curie, INSERM U520, 12 rue Lhomond, 75005 Paris, France, U520, Institut Curie;, , ,
  • Laurence Zitvogel
    Institut Curie, INSERM U520, 12 rue Lhomond, 75005 Paris, France, U520, Institut Curie;, , ,
  • Clotilde Théry
    Institut Curie, INSERM U520, 12 rue Lhomond, 75005 Paris, France, U520, Institut Curie;, , ,
  • Sebastian Amigorena
    Institut Curie, INSERM U520, 12 rue Lhomond, 75005 Paris, France, U520, Institut Curie;, , ,

説明

<jats:p>Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides, and load these peptides onto major histocompatibility complex (MHC) class I and II molecules. Dendritic cells then migrate to secondary lymphoid organs and become competent to present antigens to T lymphocytes, thus initiating antigen-specific immune responses, or immunological tolerance. Antigen presentation in dendritic cells is finely regulated: antigen uptake, intracellular transport and degradation, and the traffic of MHC molecules are different in dendritic cells as compared to other antigen-presenting cells. These specializations account for dendritic cells' unique role in the initiation of immune responses and the induction of tolerance.</jats:p>

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