Isolation and Some Biochemical Properties of the Catechol Amine Granules in the Cow Adrenal Medulla

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<jats:title>Summary.</jats:title><jats:p> <jats:list list-type="explicit-label"> <jats:list-item><jats:p>By means of density gradient centrifugation the catechol amine granules in the cow adrenal medulla have been isolated free or practically free from mitochondria and microsomal material.</jats:p></jats:list-item> <jats:list-item><jats:p>The isolated granules have a very high content of pressor amines (about 35 <jats:italic>μ</jats:italic>moles/mg protein‐N). The soluble protein fraction that is released together with the amines at osinoticlysis of the granules, represents the main part (77 per cent) of the total granule proteins.</jats:p></jats:list-item> <jats:list-item><jats:p>The granules show a high ATPase activity and probably contain an adenylate kinase.</jats:p></jats:list-item> </jats:list> </jats:p>

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