Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species
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- Eric L. Bell
- Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, U.S.A.
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- Navdeep S. Chandel
- Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, U.S.A.
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- Chris Peers
- editor
説明
<jats:p>Decreased oxygen availability (hypoxia) promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation and cell viability through the transcription factor HIF (hypoxia-inducible factor). Activation of HIF can also promote pathophysiological processes such as cancer and pulmonary hypertension. The mechanism(s) by which hypoxia activates HIF are the subject of intensive research. In this chapter we outline the model in which mitochondria regulate the stability of HIF through the increased production of ROS (reactive oxygen species) during hypoxia.</jats:p>
収録刊行物
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- Essays in Biochemistry
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Essays in Biochemistry 43 17-28, 2007-08-10
Portland Press Ltd.