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- Amany Mohamed
- Department of Pharmacology, University of Alberta, Edmonton, AB, Canada T6G 2H7
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- Elena Posse de Chaves
- Department of Pharmacology, University of Alberta, Edmonton, AB, Canada T6G 2H7
説明
<jats:p>In the brain, the amyloid<jats:italic>β</jats:italic>peptide (A<jats:italic>β</jats:italic>) exists extracellularly and inside neurons. The intracellular accumulation of A<jats:italic>β</jats:italic>in Alzheimer's disease brain has been questioned for a long time. However, there is now sufficient strong evidence indicating that accumulation of A<jats:italic>β</jats:italic>inside neurons plays an important role in the pathogenesis of Alzheimer's disease. Intraneuronal A<jats:italic>β</jats:italic>originates from intracellular cleavage of APP and from A<jats:italic>β</jats:italic>internalization from the extracellular milieu. We discuss here the different molecular mechanisms that are responsible for A<jats:italic>β</jats:italic>internalization in neurons and the links between A<jats:italic>β</jats:italic>internalization and neuronal dysfunction and death. A brief description of A<jats:italic>β</jats:italic>uptake by glia is also presented.</jats:p>
収録刊行物
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- International Journal of Alzheimer's Disease
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International Journal of Alzheimer's Disease 2011 1-17, 2011
Hindawi Limited
