Local Action with Global Impact: Highly Similar Infection Patterns of Human Viruses and Bacteriophages

DOI Web Site 1 Citations
  • Rachelle Mariano
    Department of Computer Science, University of Miami, Coral Gables, Florida, USA
  • Sawsan Khuri
    Department of Computer Science, University of Miami, Coral Gables, Florida, USA
  • Peter Uetz
    Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, USA
  • Stefan Wuchty
    Department of Computer Science, University of Miami, Coral Gables, Florida, USA
  • Sean M. Gibbons
    editor

Description

<jats:p> While host-virus interaction interfaces have been previously investigated, relatively little is known about the indirect interactions of pathogen and host proteins required for viral infection and host cell function. Therefore, we investigated the topological relationships of human and bacterial viruses and how they interact with their hosts. We focused on those host proteins that are directly targeted by viruses, those that are required for infection, and those that are essential for both human and bacterial cells (here, <jats:named-content content-type="genus-species">E. coli</jats:named-content> ). Generally, we observed that targeted, required, and essential proteins in both hosts interact in a highly intertwined fashion. While there exist highly similar topological patterns, we found that human viruses target transcription factors through methylases and acetylases, proteins that played no such role in bacteriophages. </jats:p>

Journal

  • mSystems

    mSystems 1 (2), e00030-, 2016-04-26

    American Society for Microbiology

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