-
- Alan D. Frankel
- Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143-0448;
-
- John A. T. Young
- Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115;
説明
<jats:p>Human immunodeficiency virus type 1 is a complex retrovirus encoding 15 distinct proteins. Substantial progress has been made toward understanding the function of each protein, and three-dimensional structures of many components, including portions of the RNA genome, have been determined. This review describes the function of each component in the context of the viral life cycle: the Gag and Env structural proteins MA (matrix), CA (capsid), NC (nucleocapsid), p6, SU (surface), and TM (transmembrane); the Pol enzymes PR (protease), RT (reverse transcriptase), and IN (integrase); the gene regulatory proteins Tat and Rev; and the accessory proteins Nef, Vif, Vpr, and Vpu. The review highlights recent biochemical and structural studies that help clarify the mechanisms of viral assembly, infection, and replication.</jats:p>
収録刊行物
-
- Annual Review of Biochemistry
-
Annual Review of Biochemistry 67 (1), 1-25, 1998-06
Annual Reviews
