Prevalence of Allergic Fungal Sinusitis in Refractory Chronic Rhinosinusitis in Adult Malaysians
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- Bee‐See Goh
- Department of Otorhinolaryngology, Faculty of Medicine
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- Balwant Singh Gendeh
- Department of Otorhinolaryngology, Faculty of Medicine
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- Isa Mohamed Rose
- Department of Pathology
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- Sabiha Pit
- Department of Microbiology National University of Malaysia
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- Shamim Abdul Samad
- Department of Microbiology National University of Malaysia
説明
<jats:sec><jats:title>OBJECTIVE:</jats:title><jats:p>To determine the prevalence of allergic fungal sinusitis (AFS) in refractory chronic rhinosinusitis (CRS) in adult Malaysians.</jats:p></jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING:</jats:title><jats:p>This cross‐sectional study involved 30 immunocompetent CRS patients who underwent surgery. Specimens were sent for mycology and histopathologic analysis for identification of fungi. Clinical and immunological workup was performed for atopy in all patients and controls.</jats:p></jats:sec><jats:sec><jats:title>RESULTS:</jats:title><jats:p>Fungal cultures were positive in 5 (16.7%) and 11 (36.7%) of 30 patients from nasal secretions and surgical specimens, respectively. Allergic mucin was found in 8 surgical specimens (26.7%). Hence, prevalence of AFS was 26.7%. The most common causative agent was <jats:italic>Aspergillus</jats:italic> sp. (54.5%). In 3 (37.5%) of 8 patients, AFS was found to be associated with asthma. Twenty‐five percent (2/8 patients) had aspirin intolerance, and 62.5% (5/8 patients) had elevated total immunoglobulin E levels. All patients had positive skin test reactivity to fungal allergen.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS:</jats:title><jats:p>This preliminary study suggests that AFS does exist in Malaysia. Proper handling of surgical specimens and accurate diagnosis by the pathologist and mycologist are essential.</jats:p></jats:sec>
収録刊行物
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- Otolaryngology–Head and Neck Surgery
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Otolaryngology–Head and Neck Surgery 133 (1), 27-31, 2005-07
Wiley
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キーワード
詳細情報 詳細情報について
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- CRID
- 1364233269808442112
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- ISSN
- 10976817
- 01945998
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- データソース種別
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- Crossref