-
- Karsten H. Weylandt
- Division of Medicine, Department of Hepatology, Gastroenterology and Metabolism, Rudolf-Virchow-Hospital, Charité University Medicine, 13353 Berlin, Germany
-
- Simona Serini
- Institute of General Pathology, Catholic University School of Medicine, 00168 Rome, Italy
-
- Yong Q. Chen
- The Synergistic Innovation Center for Food Safety and Nutrition, State Key Laboratory of Food Science and Technology, and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
-
- Hui-Min Su
- Department of Physiology, National Taiwan University College of Medicine, Taipei 100, Taiwan
-
- Kyu Lim
- Department of Biochemistry, School of Medicine, Cancer Research Institute, Infection Signaling Network Research Center, Chungnam National University, Daejeon 301-747, Republic of Korea
-
- Achille Cittadini
- Institute of General Pathology, Catholic University School of Medicine, 00168 Rome, Italy
-
- Gabriella Calviello
- Institute of General Pathology, Catholic University School of Medicine, 00168 Rome, Italy
抄録
<jats:p>Almost forty years ago, it was first hypothesized that an increased dietary intake of omega-3 polyunsaturated fatty acids (PUFA) from fish fat could exert protective effects against several pathologies. Decades of intense preclinical investigation have supported this hypothesis in a variety of model systems. Several clinical cardiovascular studies demonstrated the beneficial health effects of omega-3 PUFA, leading medical institutions worldwide to publish recommendations for their increased intake. However, particularly in recent years, contradictory results have been obtained in human studies focusing on cardiovascular disease and the clinical evidence in other diseases, particularly chronic inflammatory and neoplastic diseases, was never established to a degree that led to clear approval of treatment with omega-3 PUFA. Recent data not in line with the previous findings have sparked a debate on the health efficacy of omega-3 PUFA and the usefulness of increasing their intake for the prevention of a number of pathologies. In this review, we aim to examine the controversies on the possible use of these fatty acids as preventive/curative tools against the development of cardiovascular, metabolic, and inflammatory diseases, as well as several kinds of cancer.</jats:p>
収録刊行物
-
- BioMed Research International
-
BioMed Research International 2015 1-24, 2015
Hindawi Limited