The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

DOI Web Site 459 Citations
  • John Hardy
    Laboratories of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
  • Dennis J. Selkoe
    Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

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<jats:p>It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide (Aβ) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of Aβ in the brain is the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Aβ production and Aβ clearance.</jats:p>

Journal

  • Science

    Science 297 (5580), 353-356, 2002-07-19

    American Association for the Advancement of Science (AAAS)

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