The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
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- John Hardy
- Laboratories of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
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- Dennis J. Selkoe
- Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
Description
<jats:p>It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide (Aβ) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of Aβ in the brain is the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Aβ production and Aβ clearance.</jats:p>
Journal
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- Science
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Science 297 (5580), 353-356, 2002-07-19
American Association for the Advancement of Science (AAAS)
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Details 詳細情報について
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- CRID
- 1364233269821808640
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- NII Article ID
- 80015445792
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- ISSN
- 10959203
- 00368075
- http://id.crossref.org/issn/00368075
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- Data Source
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- Crossref
- CiNii Articles