Cutting Edge: Regulation of Intestinal Inflammation and Barrier Function by IL-17C

DOI PDF 7 Citations
  • Joseph M. Reynolds
    Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054
  • Gustavo J. Martinez
    Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054
  • Kalyan C. Nallaparaju
    Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054
  • Seon Hee Chang
    Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054
  • Yi-Hong Wang
    Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054
  • Chen Dong
    Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054

Description

<jats:title>Abstract</jats:title> <jats:p>In the IL-17 family of cytokines, much is known about the sources and functions of IL-17, IL-17F, and IL-25 in the host defense against infection and in inflammatory diseases; however, the physiological function of IL-17C remains poorly understood. Using mice deficient in IL-17C, we demonstrate that this cytokine is crucial for the regulation of an acute experimental colitis elicited by dextran sulfate sodium. In this model, mice lacking IL-17C exhibited exacerbated disease that was associated with increased IL-17 expression by γδ T cells and Th17 cells. Moreover, IL-17C directly regulated the expression of the tight junction molecule occludin by colonic epithelial cells. Thus, our data suggest that IL-17C plays a critical role in maintaining mucosal barrier integrity.</jats:p>

Journal

  • The Journal of Immunology

    The Journal of Immunology 189 (9), 4226-4230, 2012-11-01

    The American Association of Immunologists

Citations (7)*help

See more

Details 詳細情報について

Report a problem

Back to top