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- Harvey Lui
- Authors' Affiliations: 1Photomedicine Institute, Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute; and 2Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada
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- Jianhua Zhao
- Authors' Affiliations: 1Photomedicine Institute, Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute; and 2Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada
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- David McLean
- Authors' Affiliations: 1Photomedicine Institute, Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute; and 2Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada
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- Haishan Zeng
- Authors' Affiliations: 1Photomedicine Institute, Department of Dermatology and Skin Science, University of British Columbia and Vancouver Coastal Health Research Institute; and 2Imaging Unit, Integrative Oncology Department, British Columbia Cancer Agency Research Centre, Vancouver, British Columbia, Canada
説明
<jats:title>Abstract</jats:title> <jats:p>Raman spectroscopy is a noninvasive optical technique capable of measuring vibrational modes of biomolecules within viable tissues. In this study, we evaluated the application of an integrated real-time system of Raman spectroscopy for in vivo skin cancer diagnosis. Benign and malignant skin lesions (n = 518) from 453 patients were measured within 1 second each, including melanomas, basal cell carcinomas, squamous cell carcinomas, actinic keratoses, atypical nevi, melanocytic nevi, blue nevi, and seborrheic keratoses. Lesion classification was made using a principal component with general discriminant analysis and partial least-squares in three distinct discrimination tasks: skin cancers and precancers from benign skin lesions [receiver operating characteristic (ROC) = 0.879]; melanomas from nonmelanoma pigmented lesions (ROC = 0.823); and melanomas from seborrheic keratoses (ROC = 0.898). For sensitivities between 95% and 99%, the specificities ranged between 15% and 54%. Our findings establish that real-time Raman spectroscopy can be used to distinguish malignant from benign skin lesions with good diagnostic accuracy comparable with clinical examination and other optical-based methods. Cancer Res; 72(10); 2491–500. ©2012 AACR.</jats:p>
収録刊行物
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- Cancer Research
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Cancer Research 72 (10), 2491-2500, 2012-05-14
American Association for Cancer Research (AACR)
