Self-Treatment of Female External Genital Warts with 0.5% Podophyllotoxin Cream (Condyline®) vs Weekly Applications of 20% Podophyllin Solution

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  • Dan Hellberg
    Department of Obstetrics and Gynecology, Falun Hospital, Falun
  • Tove Svarrer
    Department of Obstetrics and Gynecology, Falun Hospital, Falun
  • Staffan Nilsson
    Department of Obstetrics and Gynecology, Falun Hospital, Falun
  • Jack Valentin
    Swedish Radiation Protection Institute, Stockholm, Sweden

説明

<jats:sec><jats:title>Summary:</jats:title><jats:p> Sixty women with genital warts were randomly allocated to treatment with either weekly application of 20% podophyllin solution or self-treatment with 0.5% podophyllotoxin cream twice daily for three days in weekly intervals. After a maximum of 4 treatment cycles a final assessment was carried out after 3 months. Primary clearance after termination of treatment was 82% for podophyllotoxin and 59% for podophyllin solution. After excluding relapses at the 3-month follow-up, final clearance for podophyllotoxin (71%) was significantly better ( P < 0.05) than that for podophyllin solution (48%). The total frequency of warts eradicated was 94% with podophyllotoxin and 74% with podophyllin solution ( P < 0.001). Local adverse effects were generally mild or moderate. Podophyllotoxin cream provides a mode of easy application for women with external genital warts and had in this study a significantly better effect than podophyllin solution. </jats:p></jats:sec>

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