-
- C. H. Tsai
- Department of Medicine, Banting and Best Diabetes Centre, TorontoHospital, University of Toronto, Ontario, Canada.
-
- M. Hill
- Department of Medicine, Banting and Best Diabetes Centre, TorontoHospital, University of Toronto, Ontario, Canada.
-
- S. L. Asa
- Department of Medicine, Banting and Best Diabetes Centre, TorontoHospital, University of Toronto, Ontario, Canada.
-
- P. L. Brubaker
- Department of Medicine, Banting and Best Diabetes Centre, TorontoHospital, University of Toronto, Ontario, Canada.
-
- D. J. Drucker
- Department of Medicine, Banting and Best Diabetes Centre, TorontoHospital, University of Toronto, Ontario, Canada.
書誌事項
- 公開日
- 1997-07-01
- DOI
-
- 10.1152/ajpendo.1997.273.1.e77
- 公開者
- American Physiological Society
この論文をさがす
説明
<jats:p> Glucagon-like peptide-2 (GLP-2) has been shown to promote intestinal epithelial proliferation. We studied crypt cell proliferation, enterocyte cell death, and feeding behavior in GLP-2-treated mice. GLP-2 had no effect on food consumption [7.7 +/- 0.3 vs. 8.0 +/- 0.4 g/day, saline (control) vs. GLP-2-treated mice, P = not significant]; however, GLP-2 increased the crypt cell proliferation rate (46.0 +/- 1 vs. 57 +/- 5%, control vs. GLP-2, P < 0.01) and decreased the enterocyte apoptotic rate (5.9 +/- 0.7 vs. 2.8 +/- 0.2% apoptotic cells, control vs. GLP-2, P < 0.05) in small bowel (SB) epithelium. GLP-2 induced a significant increase in SB weight (1.3- to 1.75-fold increase over control, P < 0.05 to P < 0.001) in mice 1-24 mo of age. Increased SB weight was maintained after daily administration of GLP-2 to mice for 12 wk, and cessation of GLP-2 administration in older mice led to regression of (increased) SB weight and mucosal height. These observations suggest that GLP-2 regulates both cell proliferation and apoptosis and promotes intestinal growth after both short- and long-term administration in vivo. </jats:p>
収録刊行物
-
- American Journal of Physiology-Endocrinology and Metabolism
-
American Journal of Physiology-Endocrinology and Metabolism 273 (1), E77-E84, 1997-07-01
American Physiological Society