[IrCl<sub>2</sub>Cp*(NHC)] Complexes as Highly Versatile Efficient Catalysts for the Cross‐Coupling of Alcohols and Amines

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<jats:title>Abstract</jats:title><jats:p>A comparative study on the catalytic activity of a series of [IrCl<jats:sub>2</jats:sub>Cp*(NHC)] complexes in several C–O and C–N coupling processes implying hydrogen‐borrowing mechanisms has been performed. The compound [IrCl<jats:sub>2</jats:sub>Cp*(I<jats:sup><jats:italic>n</jats:italic>Bu</jats:sup>)] (Cp*=pentamethyl cyclopentadiene; I<jats:sup><jats:italic>n</jats:italic>Bu</jats:sup>=1,3‐di‐<jats:italic>n</jats:italic>‐butylimidazolylidene) showed to be highly effective in the cross‐coupling reactions of amines and alcohols, providing high yields in the production of unsymmetrical ethers and N‐alkylated amines. A remarkable feature is that the processes were carried out in the absence of base, phosphine, or any other external additive. A comparative study with other known catalysts, such as Shvo's catalyst, is also reported.</jats:p>

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