Intramolecular DNA coiling mediated by metallo-supramolecular cylinders: Differential binding of P and M helical enantiomers

DOI Web Site 4 Citations
  • Isabelle Meistermann
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom; Departament de Química Inorgànica, Universitat de Barcelona, Diagonal 647, 08028 Barcelona, Spain; and Department of Chemistry, University of Bergen, Allegt 41, N-5007 Bergen, Norway
  • Virtudes Moreno
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom; Departament de Química Inorgànica, Universitat de Barcelona, Diagonal 647, 08028 Barcelona, Spain; and Department of Chemistry, University of Bergen, Allegt 41, N-5007 Bergen, Norway
  • Maria J. Prieto
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom; Departament de Química Inorgànica, Universitat de Barcelona, Diagonal 647, 08028 Barcelona, Spain; and Department of Chemistry, University of Bergen, Allegt 41, N-5007 Bergen, Norway
  • Erlend Moldrheim
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom; Departament de Química Inorgànica, Universitat de Barcelona, Diagonal 647, 08028 Barcelona, Spain; and Department of Chemistry, University of Bergen, Allegt 41, N-5007 Bergen, Norway
  • Einar Sletten
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom; Departament de Química Inorgànica, Universitat de Barcelona, Diagonal 647, 08028 Barcelona, Spain; and Department of Chemistry, University of Bergen, Allegt 41, N-5007 Bergen, Norway
  • Syma Khalid
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom; Departament de Química Inorgànica, Universitat de Barcelona, Diagonal 647, 08028 Barcelona, Spain; and Department of Chemistry, University of Bergen, Allegt 41, N-5007 Bergen, Norway
  • P. Mark Rodger
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom; Departament de Química Inorgànica, Universitat de Barcelona, Diagonal 647, 08028 Barcelona, Spain; and Department of Chemistry, University of Bergen, Allegt 41, N-5007 Bergen, Norway
  • Jemma C. Peberdy
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom; Departament de Química Inorgànica, Universitat de Barcelona, Diagonal 647, 08028 Barcelona, Spain; and Department of Chemistry, University of Bergen, Allegt 41, N-5007 Bergen, Norway
  • Christian J. Isaac
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom; Departament de Química Inorgànica, Universitat de Barcelona, Diagonal 647, 08028 Barcelona, Spain; and Department of Chemistry, University of Bergen, Allegt 41, N-5007 Bergen, Norway
  • Alison Rodger
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom; Departament de Química Inorgànica, Universitat de Barcelona, Diagonal 647, 08028 Barcelona, Spain; and Department of Chemistry, University of Bergen, Allegt 41, N-5007 Bergen, Norway
  • Michael J. Hannon
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom; Departament de Química Inorgànica, Universitat de Barcelona, Diagonal 647, 08028 Barcelona, Spain; and Department of Chemistry, University of Bergen, Allegt 41, N-5007 Bergen, Norway

Search this article

Description

<jats:p> We have designed a synthetic tetracationic metallo-supramolecular cylinder that targets the major groove of DNA with a binding constant in excess of 10 <jats:sup>7</jats:sup> M <jats:sup>−1</jats:sup> and induces DNA bending and intramolecular coiling. The two enantiomers of the helical molecule bind differently to DNA and have different structural effects. We report the characterization of the interactions by a range of biophysical techniques. The M helical cylinder binds to the major groove and induces dramatic intramolecular coiling. The DNA bending is less dramatic for the P enantiomer. </jats:p>

Journal

Citations (4)*help

See more

Details 詳細情報について

Report a problem

Back to top