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- Xiaodan Ren
- Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan
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- Bin Hu
- Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan
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- Lisa M. Colletti
- Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan
説明
<jats:p> Hepatocyte proliferation following partial hepatectomy is an important component of liver regeneration, and recent in vitro studies have shown that IL-22 is involved in cellular proliferation in a variety of cell types, including hepatocytes. IL-22 functions through IL-10Rβ and IL-22Rα. The goal of this study was to investigate the potential role of IL-22 in liver regeneration after 70% hepatectomy. Following 70% hepatectomy, done under general anesthesia in mice, serum IL-22 and hepatic IL-22Rα mRNA were significantly increased. Although administration of exogenous IL-22 prior to hepatectomy did not increase hepatocyte proliferation, administration of anti-IL-22 antibody before hepatectomy did significantly decrease hepatocyte proliferation. Furthermore, IL-22 treatment prior to 70% hepatectomy induced stat-3 activation; no significant changes were seen in ERK1/2 activation, stat-1 activation, or stat-5 activation. IL-22 pretreatment also significantly increased hepatic and serum IL-6 levels. In addition, animals treated with anti-IL-22 antibody also expressed less TGF-α. In conclusion, these data suggest that IL-22 is involved in liver regeneration and this may be due to interaction with IL-6 and TGF-α cascades. </jats:p>
収録刊行物
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- American Journal of Physiology-Gastrointestinal and Liver Physiology
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American Journal of Physiology-Gastrointestinal and Liver Physiology 298 (1), G74-G80, 2010-01
American Physiological Society