Metformin Suppresses Interleukin (IL)-1β-Induced IL-8 Production, Aromatase Activation, and Proliferation of Endometriotic Stromal Cells

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  • Yuri Takemura
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan
  • Yutaka Osuga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan
  • Osamu Yoshino
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan
  • Akiko Hasegawa
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan
  • Tetsuya Hirata
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan
  • Yasushi Hirota
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan
  • Emi Nose
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan
  • Chieko Morimoto
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan
  • Miyuki Harada
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan
  • Kaori Koga
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan
  • Toshiki Tajima
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan
  • Tetsu Yano
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan
  • Yuji Taketani
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan

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<jats:title>Abstract</jats:title> <jats:p>Context: Metformin, a widely used treatment for diabetes that improves insulin sensitivity, also has both antiinflammatory properties and a modulatory effect on ovarian steroid production, two actions that have been suggested to be efficacious in therapy for endometriosis.</jats:p> <jats:p>Objective: To determine whether metformin may be effective for the treatment of endometriosis, we evaluated the effects of this agent on inflammatory response, estradiol production, and proliferation of endometriotic stromal cells (ESCs).</jats:p> <jats:p>Design: ESCs derived from ovarian endometriomas were cultured with various concentrations of metformin.</jats:p> <jats:p>Main Outcome Measures: IL-8 production, mRNA expression and aromatase activity, and 5-bromo-2′-deoxyuridine incorporation in ESCs were measured.</jats:p> <jats:p>Results: Metformin dose-dependently suppressed IL-1β-induced IL-8 production, cAMP-induced mRNA expression and aromatase activity, and 5-bromo-2′-deoxyuridine incorporation in ESCs.</jats:p> <jats:p>Conclusion: These results suggest that further investigation into the unique therapeutic potential of metformin as an antiendometriotic drug is warranted.</jats:p>

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