Sole abnormalities of chromosome 7 in myeloid malignancies: Spectrum, histopathologic correlates, and prognostic implications

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<jats:title>Abstract</jats:title><jats:p>Among 6,565 consecutive abnormal cytogenetic reports at our institution, 3,192 (49%) constituted sole abnormalities, of which 230 (7%) involved chromosome 7: monosomy 7 (<jats:italic>n</jats:italic> = 98), 7q‐ (<jats:italic>n</jats:italic> = 51), der(1;7)(q10;p10) (<jats:italic>n</jats:italic> = 44), balanced translocations (<jats:italic>n</jats:italic> = 15), ring 7 (<jats:italic>n</jats:italic> = 13), and 7p‐ (<jats:italic>n</jats:italic> = 9). The most frequent histopathologic correlates were myelodysplastic syndromes (MDS; 28%), acute myeloid leukemia (AML; 17%), secondary or therapy‐related MDS/AML (13%), primary myelofibrosis (PMF; 7%), and chronic myelomonocytic leukemia (6%). Monosomy 7 was the most frequent in each one of these disease categories except PMF where 7q‐ was more frequent. In primary MDS, patients with der(1;7)(q10;p10) (<jats:italic>n</jats:italic> = 13), compared to those with monosomy 7 (<jats:italic>n</jats:italic> = 30) or 7q‐ (<jats:italic>n</jats:italic> = 15), were less likely (<jats:italic>P</jats:italic> = 0.04) to display excess blasts or multilineage dysplasia but overall and leukemia‐free survival adjusted for these variables revealed no significant difference between the three groups (<jats:italic>P</jats:italic> = 0.57 and 0.81, respectively). The current study does not prognostically distinguish monosomy 7 from 7q‐ or der(1;7), in MDS. Am. J. Hematol. 87:684–686, 2012. © 2012 Wiley Periodicals, Inc.</jats:p>

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