Role of cholesterol in fusion of Semliki Forest virus with membranes

書誌事項

公開日
1984-10
権利情報
  • https://journals.asm.org/non-commercial-tdm-license
DOI
  • 10.1128/jvi.52.1.281-283.1984
公開者
American Society for Microbiology

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説明

<jats:p>The low pH-triggered membrane fusion activity of Semliki Forest virus is dependent on the presence of cholesterol in the target membrane. When liposomes containing phospholipids and cholesterol analogs were used, fusion activity was observed with steroids which did not have a planar nucleus or an isooctyl side chain at C-17, but fusion activity was not observed when analogs which lacked the 3 beta-OH group were used. Binding of virus to liposomes at low pH was similarly, but not totally, dependent on the presence of a 3 beta-OH sterol.</jats:p>

収録刊行物

  • Journal of Virology

    Journal of Virology 52 (1), 281-283, 1984-10

    American Society for Microbiology

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