Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: A review

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  • Milad Ashrafizadeh
    Department of Basic Science, Faculty of Veterinary Medicine University of Tabriz Tabriz Iran
  • Hossein Rafiei
    Department of Biology, Faculty of Sciences, Shiraz Branch Islamic Azad University Shiraz Iran
  • Reza Mohammadinejad
    Pharmaceutics Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences Kerman Iran
  • Elham G. Afshar
    Neuroscience Research Center, Institute of Neuropharmacology Kerman University of Medical Sciences Kerman Iran
  • Tahereh Farkhondeh
    Cardiovascular Diseases Research Center Birjand University of Medical Sciences Birjand Iran
  • Saeed Samarghandian
    Healthy Ageing Research Center Neyshabur University of Medical Sciences Neyshabur Iran

Abstract

<jats:title>Abstract</jats:title><jats:p>Curcumin is a naturally occurring nutraceutical compound with a number of therapeutic and biological activities such as antioxidant, anti‐inflammatory, anti‐diabetic, antitumor, and cardioprotective. This plant‐derived chemical has demonstrated great potential in targeting various signaling pathways to exert its protective effects. Signal transducers and activator of transcription (STAT) is one of the molecular pathways involved in a variety of biological processes such as cell proliferation and cell apoptosis. Accumulating data demonstrates that the STAT pathway is an important target in treatment of a number of disorders, particularly cancer. Curcumin is capable of affecting STAT signaling pathway in induction of its therapeutic impacts. Curcumin is able to enhance the level of anti‐inflammatory cytokines and improve inflammatory disorders such as colitis by targeting STAT signaling pathway. Furthermore, studies show that inhibition of JAK/STAT pathway by curcumin is involved in reduced migration and invasion of cancer cells. Curcumin normalizes the expression of JAK/STAT signaling pathway to exert anti‐diabetic, renoprotective, and neuroprotective impacts. At the present review, we provide a comprehensive discussion about the effect of curcumin on JAK/STAT signaling pathway to direct further studies in this field.</jats:p>

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