Melatonin: Exceeding Expectations

DOI Web Site 6 Citations
  • Russel J. Reiter
    Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas; and
  • Dun Xian Tan
    Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas; and
  • Annia Galano
    Departamento de Quimica, Universidad Autonoma Metropolitana-Iztapalapa, Mexico D.F., Mexico

Abstract

<jats:p>Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer inhibition. The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart attack), ionizing radiation, and drug toxicity, among others. Melatonin has numerous applications in physiology and medicine.</jats:p>

Journal

  • Physiology

    Physiology 29 (5), 325-333, 2014-09

    American Physiological Society

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