Peritoneal Air Exposure Elicits an Intestinal Inflammation Resulting in Postoperative Ileus
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- Shanjun Tan
- Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China
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- Wenkui Yu
- Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China
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- Zhiliang Lin
- Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China
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- Qiyi Chen
- Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China
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- Jialiang Shi
- Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China
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- Yi Dong
- Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China
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- Kaipeng Duan
- Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China
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- Xiaowu Bai
- Research Institute of General Surgery, Jinling Hospital, Clinical School of Nanjing, Second Military Medical University, 305 East Zhongshan Road, Nanjing 210002, China
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- Lin Xu
- Research Institute of General Surgery, Jinling Hospital, Clinical School of Nanjing, Second Military Medical University, 305 East Zhongshan Road, Nanjing 210002, China
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- Jieshou Li
- Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China
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- Ning Li
- Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, China
抄録
<jats:p><jats:italic>Background.</jats:italic>The pathogenesis of postoperative ileus (POI) is complex. The present study was designed to investigate the effects of peritoneal air exposure on the POI intestinal inflammation and the underlying mechanism.<jats:italic>Methods.</jats:italic>Sprague-Dawley rats were randomized into five groups (6/group): the control group, the sham group, and three exposure groups with peritoneal air exposure for 1, 2, or 3 h. At 24 h after surgery, we analyzed the gastrointestinal transit, the serum levels of tumor necrosis factor (TNF)-<jats:italic>α</jats:italic>, interleukin (IL)-1<jats:italic>β</jats:italic>, IL-6, and IL-10, the myeloperoxidase activity, and the levels of TNF-<jats:italic>α</jats:italic>, IL-1<jats:italic>β</jats:italic>, IL-6, and IL-10 in the ileum and colon. The oxidant and antioxidant levels in the ileum and colon were analyzed by measuring malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and total antioxidant capacity (T-AOC).<jats:italic>Results.</jats:italic>Peritoneal air exposure caused an air-exposure-time-dependent decrease in the gastrointestinal transit. The length of peritoneal air exposure is correlated with the severity of both systemic and intestinal inflammations and the increases in the levels of MDA, SOD, GSH-Px, and T-AOC.<jats:italic>Conclusions.</jats:italic>The length of peritoneal air exposure is proportional to the degree of intestinal paralysis and the severity of intestinal inflammation, which is linked to the oxidative stress response.</jats:p>
収録刊行物
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- Mediators of Inflammation
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Mediators of Inflammation 2014 1-11, 2014
Hindawi Limited
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キーワード
詳細情報 詳細情報について
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- CRID
- 1364233271122680320
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- ISSN
- 14661861
- 09629351
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- データソース種別
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- Crossref