MANAGEMENT OF ENDOCRINE DISEASE: Acromegaly and cancer: an old debate revisited

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  • Cesar Luiz Boguszewski
    1Department of Internal MedicineEndocrine Division (SEMPR), Federal University of Paraná, Curitiba, Brazil
  • John Ayuk
    2Consultant Endocrinologist/Honorary Senior LecturerDepartment of Endocrinology, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK

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<jats:p>Based on experimental and animal models, epidemiological data from non-acromegaly populations, and longitudinal and cross-sectional cohorts of patients with acromegaly, a potential association between acromegaly and cancer has long been hypothesized, in particular colorectal cancer, and, to a lesser extent, breast, thyroid and prostate cancers. The exact mechanisms underlying this potential association have not been fully elucidated. Results from studies examining cancer incidence and mortality in acromegaly have been inconsistent, with some demonstrating increased risk, whereas others show no increase. This article reviews the existing data relating to cancer risk and mortality in acromegaly, exploring the limitations of study designs and the impact of changes in disease control and patient outcomes over time.</jats:p>

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