Center for Cardiovascular Research, John Milliken Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, U.S.A., and the Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, U.S.A. (At 2008-09-03)