From Duke Clinical Research Institute, Durham, NC (R.M.C., K.S.P., K.L.L.); University Hospital Gasthuisberg, Leuven, Belgium (F.V.d.W.); NHMRC Clinical Trials Centre, University of Sydney, NSW, Australia (R.J.S.); University of Alberta, Edmonton, Canada (P.W.A.); and the Cleveland Clinic Foundation, Cleveland, Ohio (E.J.T.). (At 2000-05-16)