From the Department of Pharmacology (W.A.A., M.T., B.R.M., T.J.J., S.M.N.), College of Pharmacy; and Department of Medicine (S.R., S.M.N.), College of Medicine, University of Toledo, Ohio; and Department of Pediatrics (R.J.K.), Medical University of South Carolina, Charleston. Present address for T.J.J.: Pharmaceutical Sciences, Northeastern Universities Colleges of Medicine and Pharmacy, Rootstown, Ohio. (At 2009-04-10)